Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis.

@article{Joksimovic2014WntcateninSI,
  title={Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis.},
  author={Milan Joksimovic and Rajeshwar Awatramani},
  journal={Journal of molecular cell biology},
  year={2014},
  volume={6 1},
  pages={27-33}
}
Loss of midbrain dopaminergic (mDA) neurons underlies the motor symptoms of Parkinson's disease. Towards cell replacement, studies have focused on mechanisms underlying embryonic mDA production, as a rational basis for deriving mDA neurons from stem cells. We will review studies of β-catenin, an obligate component of the Wnt cascade that is critical to mDA specification and neurogenesis. mDA neurons have a unique origin--the midbrain floor plate (FP). Unlike the hindbrain and spinal cord FP… CONTINUE READING
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