Wnt/β-catenin signaling controls development of the blood–brain barrier

  title={Wnt/β-catenin signaling controls development of the blood–brain barrier},
  author={Stefan Liebner and Monica Corada and Thorsten Bangsow and Jane W Babbage and Andrea Taddei and Cathrin J. Czupalla and Marco Antonio Sousa Reis and Angelina Felici and Hartwig Wolburg and Marcus Fruttiger and Makoto Mark Taketo and Harald von Melchner and Karl Heinz Plate and Holger Gerhardt and Elisabetta Dejana},
  journal={The Journal of Cell Biology},
  pages={409 - 417}
The blood-brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and maintenance of BBB characteristics during embryonic and postnatal development. Endothelial specific stabilization of beta-cat in vivo enhances barrier maturation, whereas inactivation of beta-cat causes significant down-regulation of claudin3 (Cldn3… CONTINUE READING
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