Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors.

Abstract

BACKGROUND Abnormal β-catenin immunohistochemistry and mutations of the β-catenin gene (CTNNB1) have been reported in adrenocortical adenomas (ACAs), but the frequencies of these defects and the phenotype of such tumors have not been clearly determined. OBJECTIVE The objective of the study was to describe the Wnt/β-catenin pathway alterations in 100 ACAs… (More)
DOI: 10.1210/jc.2010-1885

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@article{Bonnet2011WntcateninPA, title={Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors.}, author={St{\'e}phane Bonnet and S{\'e}bastien Gaujoux and Pierre Launay and C. Baudry and Ilham Chokri and Bruno Ragazzon and Rossella Lib{\'e} and Fernande Ren{\'e}-Corail and Anne Audebourg and Marie-C{\'e}cile Vacher-Lavenu and Lionel Groussin and Xavier Y Bertagna and Bertrand Dousset and J{\'e}r{\^o}me Bertherat and Fr{\'e}d{\'e}rique Tissier}, journal={The Journal of clinical endocrinology and metabolism}, year={2011}, volume={96 2}, pages={E419-26} }