Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.

@article{Lander2016WntPA,
  title={Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.},
  author={Rachel Mae Lander and Christian P Petersen},
  journal={eLife},
  year={2016},
  volume={5}
}
Mechanisms enabling positional identity re-establishment are likely critical for tissue regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is known about how regeneration signaling restores regionalization along body or organ axes. We identify three genes expressed constitutively in overlapping body-wide transcriptional gradients that control trunk-tail positional identity in regeneration. ptk7 encodes a trunk-expressed… CONTINUE READING

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