Within the twilight zone: a sensitive profile-profile comparison tool based on information theory.

@article{Yona2002WithinTT,
  title={Within the twilight zone: a sensitive profile-profile comparison tool based on information theory.},
  author={Golan Yona and Michael Levitt},
  journal={Journal of molecular biology},
  year={2002},
  volume={315 5},
  pages={1257-75}
}
This paper presents a novel approach to profile-profile comparison. The method compares two input profiles (like those that are generated by PSI-BLAST) and assigns a similarity score to assess their statistical similarity. Our profile-profile comparison tool, which allows for gaps, can be used to detect weak similarities between protein families. It has also been optimized to produce alignments that are in very good agreement with structural alignments. Tests show that the profile-profile… CONTINUE READING
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