Within-subject biological variation in disease: collated data and clinical consequences.

  title={Within-subject biological variation in disease: collated data and clinical consequences.},
  author={Carmen Ric{\'o}s and Natalia Iglesias and Jos{\'e}-Vicente Garc{\'i}a-Lario and Margarita Sim{\'o}n and Fernando Cava and Amparo Hern{\'a}ndez and Carmen Perich and Joanna Minchinela and Virtudes {\'A}lvarez and M. Domenech and C Jim{\'e}nez and Carmen Biosca and Raquel Tena},
  journal={Annals of clinical biochemistry},
  volume={44 Pt 4},
Quantitative data on the components of biological variation (BV) are used for several purposes, including calculating the reference change value (RCV) required for the assessment of the significance of changes in serial results in an individual. Pathology may modify the set point in diseased patients and, more importantly, the variation around that set-point. Our aim was to collate all published BV data in situations other than health. We report the within-subject coefficient of variation (CV(I… CONTINUE READING

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