Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin.

@article{Tanabe2013WithinpopulationGD,
  title={Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin.},
  author={Kazuyuki Tanabe and Toshihiro Mita and Nirianne M Q Palacpac and Nobuko Arisue and Takahiro Tougan and Satoru Kawai and Thibaut Jombart and Fumie Kobayashi and Toshihiro Horii},
  journal={Vaccine},
  year={2013},
  volume={31 9},
  pages={
          1334-9
        }
}
Populations of Plasmodium falciparum, the most virulent human malaria parasite, are diverse owing to wide levels of transmission and endemicity of infection. Genetic diversity of P. falciparum antigens, within and between parasite populations, remains a confounding factor in malaria pathogenesis as well as clinical trials of vaccine candidates. Variation of target antigens in parasite populations may arise from immune pressure depending on the levels of acquired immunity. Alternatively, similar… CONTINUE READING

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