Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure.

@article{Grad2014WithinhostWD,
  title={Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure.},
  author={Yonatan H. Grad and Ruchi M. Newman and Michael C. Zody and Xiao Yang and Ryan Murphy and James Qu and Christine M. Malboeuf and Joshua Z. Levin and Marc Lipsitch and John P. Devincenzo},
  journal={Journal of virology},
  year={2014},
  volume={88 13},
  pages={
          7286-93
        }
}
UNLABELLED Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in infants and young children and an important respiratory pathogen in the elderly and immunocompromised. While population-wide molecular epidemiology studies have shown multiple cocirculating RSV genotypes and revealed antigenic and genetic change over successive seasons, little is known about the extent of viral diversity over the course of an individual infection, the origins of novel… CONTINUE READING

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