Within-host virus models with periodic antiviral therapy.

@article{Leenheer2009WithinhostVM,
  title={Within-host virus models with periodic antiviral therapy.},
  author={Patrick De Leenheer},
  journal={Bulletin of mathematical biology},
  year={2009},
  volume={71 1},
  pages={189-210}
}
This paper investigates the effect of drug treatment on the standard within-host virus model, assuming that therapy occurs periodically. It is shown that eradication is possible under these periodic regimens, and we quantitatively characterize successful drugs or drug combinations, both theoretically and numerically. We also consider certain optimization problems, motivated for instance, by the fact that eradication should be achieved at acceptable toxicity levels to the patient. It turns out… CONTINUE READING
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