Within- and between-species DNA sequence variation and the 'footprint' of natural selection.

  title={Within- and between-species DNA sequence variation and the 'footprint' of natural selection.},
  author={Hiroshi Akashi},
  volume={238 1},
Extensive DNA data emerging from genome-sequencing projects have revitalized interest in the mechanisms of molecular evolution. Although the contribution of natural selection at the molecular level has been debated for over 30 years, the relevant data and appropriate statistical methods to address this issue have only begun to emerge. This paper will first present the predominant models of neutral, nearly neutral, and adaptive molecular evolution. Then, a method to identify the role of natural… CONTINUE READING


Publications citing this paper.
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Publications referenced by this paper.
Showing 1-10 of 60 references

simulans: reduced codon bias, faster rates of amino acid

  • D. ter
  • 1969
Highly Influential
4 Excerpts

On the probability of fixation of mutant genes in a population

  • M. Kimura
  • Genetics
  • 1962
Highly Influential
5 Excerpts

Departure from neutrality atsites in Drosophila genes are not neutral : evidence of selection among synonymous codons

  • C. A. Wise, M. Sraml, S. Easteal
  • Mol . Biol . Evol .
  • 1998

Likelihood models for detecting positivelycodon usage

  • T. M. envelopeCollins, P. H. Wimberger, G. J. P. Naylor
  • Genetics
  • 1998

The role of gene conversion in determining sequence

  • L. M. 1297–1307. King
  • 1998
2 Excerpts

Translational selection and molecu - 260 , 91 – 95 . lar evolution

  • J. H. McDonald, M. Kreitman
  • Curr . Opin . Genet . Dev .
  • 1998

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