Withdrawal of the aldose reductase inhibitor tolrestat in patients with diabetic neuropathy: effect on nerve function. The Tolrestat Study Group.

Abstract

A double-blind, placebo-controlled clinical trial was conducted to study the effects of discontinuing tolrestat, an aldose reductase inhibitor, on peripheral sensorimotor diabetic neuropathy. After an average of 4.2 years of continuous tolrestat use, 372 patients were randomly assigned to either placebo or continued tolrestat therapy and were followed for… (More)

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Cite this paper

@article{Santiago1993WithdrawalOT, title={Withdrawal of the aldose reductase inhibitor tolrestat in patients with diabetic neuropathy: effect on nerve function. The Tolrestat Study Group.}, author={Jimenez Valero Santiago and P H Snksen and Andrew Boulton and Andrew F Macleod and Mim Beg and W. J. Bochenek and geb. Graepel and Boas Gonen}, journal={Journal of diabetes and its complications}, year={1993}, volume={7 3}, pages={170-8} }