Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.

@article{LeNiculescu1999WithdrawalOS,
  title={Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.},
  author={Helen Le-Niculescu and E Bonfoco and Yoshitoshi Kasuya and François X. Claret and Douglas R Green and Michael Karin},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 1},
  pages={751-63}
}
The JNK pathway modulates AP-1 activity. While in some cells it may have proliferative and protective roles, in neuronal cells it is involved in apoptosis in response to stress or withdrawal of survival signals. To understand how JNK activation leads to apoptosis, we used PC12 cells and primary neuronal cultures. In PC12 cells, deliberate JNK activation is followed by induction of Fas ligand (FasL) expression and apoptosis. JNK activation detected by c-Jun phosphorylation and FasL induction are… CONTINUE READING
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