Withdrawal of inhaled glucocorticoids and exacerbations of COPD.

  title={Withdrawal of inhaled glucocorticoids and exacerbations of COPD.},
  author={H. Magnussen and Bernd Disse and Robert 6 Rodriguez-Roisin and Anne M Kirsten and Henrik Watz and Kay Tetzlaff and Lesley Towse and Helen A Finnigan and Ronald Dahl and Marc Decramer and Pascal Chanez and Emiel F. M. Wouters and Peter Mark Anthony Calverley},
  journal={The New England journal of medicine},
  volume={371 14},
BACKGROUND Treatment with inhaled glucocorticoids in combination with long-acting bronchodilators is recommended in patients with frequent exacerbations of severe chronic obstructive pulmonary disease (COPD). However, the benefit of inhaled glucocorticoids in addition to two long-acting bronchodilators has not been fully explored. METHODS In this 12-month, double-blind, parallel-group study, 2485 patients with a history of exacerbation of COPD received triple therapy consisting of tiotropium… CONTINUE READING