Withdrawal-like behavior in planarians is dependent on drug exposure duration.

@article{Sacavage2008WithdrawallikeBI,
  title={Withdrawal-like behavior in planarians is dependent on drug exposure duration.},
  author={Steve Sacavage and Hiren C. Patel and Mike Zielinski and Jeneane Acker and Austin G. Phillips and Robert B Raffa and Scott Manning Rawls},
  journal={Neuroscience letters},
  year={2008},
  volume={439 1},
  pages={84-8}
}
Planarians display a concentration-related reduction in locomotor activity following their spontaneous withdrawal from opioids, cannabinoids, stimulants and benzodiazepines. This suggests that planarians display a withdrawal-like behavior that can be quantified as a reduction in locomotor activity. Because withdrawal-like behavior in previous studies has been quantified only following the cessation of a 60-min drug exposure, it is unclear whether the withdrawal response varies with drug… CONTINUE READING
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