Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.

@article{King1994WithdrawalFC,
  title={Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.},
  author={George R King and Everett H. Ellinwood and Copelli Silvia and Catherine M. Joyner and Zhengyu Y Xue and Marc G. Caron and Tong H. Lee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 2},
  pages={743-9}
}
Intermittent cocaine administration produces sensitization, whereas the continuous administration of cocaine produces tolerance to the effects of subsequent cocaine administration during withdrawal. The present study examined whether the effects of these two dosing regimens are related to alterations in the functional status of dopamine (DA) D2 receptors. In all experiments, rats were withdrawn for 7 days from a 14-day pretreatment regimen involving either continuous or intermittent cocaine… CONTINUE READING

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