Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats.

@article{Calu2007WithdrawalFC,
  title={Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats.},
  author={Donna J Calu and Thomas A Stalnaker and Theresa M. Franz and Teghpal Singh and Yavin Shaham and Geoffrey Schoenbaum},
  journal={Learning & memory},
  year={2007},
  volume={14 5},
  pages={325-8}
}
Drug addicts make poor decisions. These decision-making deficits have been modeled in addicts and laboratory animals using reversal-learning tasks. However, persistent reversal-learning impairments have been shown in rats and monkeys only after noncontingent cocaine injections. Current thinking holds that to represent the human condition effectively, animal models of addiction must utilize self-administration procedures in which drug is earned contingently; thus, it remains unclear whether… CONTINUE READING

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