Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice.

@article{Darmani1990WithdrawalFC,
  title={Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice.},
  author={Nissar A. Darmani and Billy R. Martin and Richard A Glennon},
  journal={European journal of pharmacology},
  year={1990},
  volume={186 1},
  pages={115-8}
}
Mice were injected once daily for 13 days with (+/-)-DOI ((+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) and the induced head-twitch response (HTR) was scored. On days 2-5 HTR was reduced to less than 50% of day 1, and then returned to control levels by day 13. Challenge doses of (+/-)-DOI administered on days 15, 17 or 19 elicited significantly exaggerated responses. Thus, chronic treatment with (+/-)-DOI may cause an initial down-regulation followed by an up-regulation of 5-HT2 receptor… CONTINUE READING

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