Withdrawal from chronic cocaine administration induces deficits in brain reward function in C57BL/6J mice.

@article{Stoker2011WithdrawalFC,
  title={Withdrawal from chronic cocaine administration induces deficits in brain reward function in C57BL/6J mice.},
  author={Astrid K. Stoker and Athina Markou},
  journal={Behavioural brain research},
  year={2011},
  volume={223 1},
  pages={176-81}
}
Anhedonia is a major symptom of cocaine withdrawal, whereas euphoria characterizes the effects of acute administration of this drug in humans. These mood states can be measured quantitatively in animals with brain reward thresholds obtained from the intracranial self-stimulation (ICSS) procedure. Studies have previously reported the reward-enhancing effects of acute cocaine administration using the ICSS procedure in mice, but the effects of chronic cocaine administration and withdrawal on brain… CONTINUE READING