Withdrawal from Fixed-Dose Injection of Methamphetamine Decreases Cerebral Levels of 3-Methoxy-4-hydroxyphenylglycol and Induces the Expression of Anxiety-Related Behavior in Mice

@article{Kitanaka2010WithdrawalFF,
  title={Withdrawal from Fixed-Dose Injection of Methamphetamine Decreases Cerebral Levels of 3-Methoxy-4-hydroxyphenylglycol and Induces the Expression of Anxiety-Related Behavior in Mice},
  author={Nobue Kitanaka and Junichi Kitanaka and Tomohiro Tatsuta and Koh-ichi Tanaka and Kaname Watabe and Nobuyoshi Nishiyama and Yoshio Morita and Motohiko Takemura},
  journal={Neurochemical Research},
  year={2010},
  volume={35},
  pages={749-760}
}
A variety of drug treatment regimens have been proposed to model the dysphoric state observed during methamphetamine (METH) withdrawal in rats, but little has been established in experiments using mice. In male ICR mice, a fixed-dose injection regimen of METH (1.0 or 2.5 mg/kg, i.p., twice daily for 10 consecutive days) induced a significant decrease in the time spent in open arms in an elevated plus maze after 5 days of drug abstinence. Under an escalating-dose injection regimen (0.2–2.0 mg/kg… CONTINUE READING

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