Withdrawal from Cocaine Self-administration and Yoked Cocaine Delivery Dysregulates Glutamatergic mGlu5 and NMDA Receptors in the Rat Brain

@inproceedings{PomiernyChamiolo2014WithdrawalFC,
  title={Withdrawal from Cocaine Self-administration and Yoked Cocaine Delivery Dysregulates Glutamatergic mGlu5 and NMDA Receptors in the Rat Brain},
  author={Lucyna Pomierny-Chamiolo and Joanna Miszkiel and Małgorzata Frankowska and Bartosz Pomierny and Ewa Niedzielska and Irena Smaga and Fabio Fumagalli and Małgorzata Filip},
  booktitle={Neurotoxicity Research},
  year={2014}
}
In human addicts and in animal models, chronic cocaine use leads to numerous alterations in glutamatergic transmission, including its receptors. The present study focused on metabotropic glutamatergic receptors type 5 (mGluR5) and N-methyl-D-aspartate receptor subunits (NMDAR: GluN1, GluN2A, GluN2B) proteins during cocaine self-administration and after 10-day of extinction training in rats. To discriminate the contingent from the non-contingent cocaine delivery, we employed the “yoked”-triad… CONTINUE READING