Withdrawal Symptoms and Rebound Syndromes Associated with Switching and Discontinuing Atypical Antipsychotics: Theoretical Background and Practical Recommendations

@article{Cerovecki2013WithdrawalSA,
  title={Withdrawal Symptoms and Rebound Syndromes Associated with Switching and Discontinuing Atypical Antipsychotics: Theoretical Background and Practical Recommendations},
  author={Anja Cerovecki and Richard Musil and Ansgar Klimke and Florian Hannes Seem{\"u}ller and Ekkehard Haen and Rebecca Schennach and K U K{\"u}hn and Hans-Peter Volz and Michael Riedel},
  journal={CNS Drugs},
  year={2013},
  volume={27},
  pages={545-572}
}
With the widespread use of atypical or second-generation antipsychotics, switching treatment has become current practice and more complicated, as the pharmacological profiles of these agents differ substantially despite their similarity in being ‘atypical’. All share the ability to block dopamine D2 receptors, and most of them also block serotonin 5-HT2A receptors. Apart from these common features, some atypical antipsychotics are also able to block or stimulate other dopamine or serotonin… CONTINUE READING
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