Withdrawal Reactions Associated with Venlafaxine

@article{Parker1998WithdrawalRA,
  title={Withdrawal Reactions Associated with Venlafaxine},
  author={Gordon Parker and Jenny Blennerhassett},
  journal={Australian and New Zealand Journal of Psychiatry},
  year={1998},
  volume={32},
  pages={291 - 294}
}
Objective: The aim of this paper is to describe discontinuation syndromes associated with abrupt and tapered withdrawal of venlafaxine, and to document that withdrawal symptoms may occur after missing a single dose. Clinical picture: We report on two patients prescribed venlafaxine. One developed a broad range of serious side effects after reaching a dose of 300 mg a day, and a severe withdrawal syndrome (including hallucinations) during a slow taper regime. The second had severe… 
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References

SHOWING 1-10 OF 12 REFERENCES
Serotonin reuptake inhibitor discontinuation syndrome: a hypothetical definition. Discontinuation Consensus panel.
TLDR
A group of experts convened in Phoenix, Arizona, to develop a clear description or definition of the SRI discontinuation syndrome, which is distinctly different from the classic withdrawal syndrome associated with alcohol and barbiturates and may be minimized by slowly tapering antidepressant therapy.
Clinical management of antidepressant discontinuation.
To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life. Agents with
Serotonin reuptake inhibitor withdrawal.
TLDR
Reports of withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective SSRIs, fluoxetine, fluvoxamine, paroxettine, or sertraline suggest a role has been suggested for serotonin in coordinating sensory and autonomic function with motor activity.
A double‐blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia
TLDR
The antidepressant efficacy and short-term safety of venlafaxine and fluoxetine were compared in 68 patients hospitalized with major depression and melancholia and overall tolerance was similar for the two treatments.
The serotonin syndrome.
  • H. Sternbach
  • Medicine, Psychology
    The American journal of psychiatry
  • 1991
TLDR
The serotonin syndrome is a toxic condition requiring heightened clinical awareness for prevention, recognition, and prompt treatment, and further work is needed to establish the diagnostic criteria, incidence, and predisposing factors.
Lithium-Induced Neurotoxicity at Serum Lithium Levels within the Therapeutic Range
  • D. Arya
  • Medicine, Psychology
    The Australian and New Zealand journal of psychiatry
  • 1996
TLDR
Even when serum lithium levels are within the therapeutic range, lithium-induced neurotoxicity may occur, and patients on neuroleptics and the elderly in particular may be more vulnerable to these side effects.
Venlafaxine withdrawal reactions.
Venlafaxine Withdrawal Symptoms
  • F. Benazzi
  • Psychology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1996
Possible venlafaxine withdrawal syndrome.
...
...