Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.

@article{Ichikawa2006WithanolidesPA,
  title={Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.},
  author={Haruyo Ichikawa and Yasunari Takada and Shishir Shishodia and Bolleddula Jayaprakasam and Muraleedharan G Nair and Bharat Bhushan Aggarwal},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 6},
  pages={1434-45}
}
The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells. Because several genes that regulate cellular proliferation, carcinogenesis… CONTINUE READING
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