Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

@inproceedings{Henrich2015WithanolideES,
  title={Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation},
  author={Curtis J. Henrich and Anne Brooks and Kristen L. Erickson and Cheryl L. Thomas and Heidi R Bokesch and Poonam Tewary and Charlotte R Thompson and Richard J. Pompei and Kirk R Gustafson and James Brislin McMahon and Thomas Joseph Sayers},
  booktitle={Cell Death and Disease},
  year={2015}
}
Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-sensitizing withanolides identified, enhanced death receptor-mediated apoptotic signaling by a rapid decline in the levels of cFLIP proteins. Other mechanisms by which TRAIL… CONTINUE READING