• DOI:10.1007/978-1-4614-3381-1_20
Corpus ID: 21937968

Withanolide D, carrying the baton of Indian rasayana herb as a lead candidate of antileukemic agent in modern medicine.

@article{Mondal2012WithanolideDC,
  title={Withanolide D, carrying the baton of Indian rasayana herb as a lead candidate of antileukemic agent in modern medicine.},
  author={Susmita Mondal and S. Roy and R. Maity and Asish Mallick and R. Sangwan and S. Misra-Bhattacharya and C. Mandal},
  journal={Advances in experimental medicine and biology},
  year={2012},
  volume={749},
  pages={
          295-312
        }
}

• Susmita Mondal, S. Roy, +4 authors C. Mandal
• Published 2012
• Medicine
• Advances in experimental medicine and biology

During cancer, immune system gets suppressed due to developing malignancy and anticancer drugs used. Therefore, an ideal chemotherapeutic agent would have both immuno-stimulatory and cancer cell death-inducing activity. Here, we have shown that Withanolide D (WithaD), an important bioactive withanolide, purified from the leaves of an Indian chemotype (NMITLI 135) of Withania somnifera acts as stimulator of Th1 response along with moderate effect on Th2 response, thus advocates its candidature… Expand

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