Withania somnifera: An Indian ginseng

 Withania somnifera: An Indian ginseng},
  author={S. Kulkarni and A. Dhir},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • S. Kulkarni, A. Dhir
  • Published 2008
  • Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Withania somnifera, popularly known as Ashwagandha is widely considered as the Indian ginseng. In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity. Having wide range of activity, it is used to treat almost all disorders that affect the human health. The present review discusses the pharmacological basis of the use of W. somnifera in various central nervous system (CNS… Expand
Chemistry and pharmacology of withania somnifera: An update
Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it is used as tonic to rejuvenate theExpand
Neuromodulatory Role of Withania somnifera
W. somnifera can be incorporated as an important dietary supplement for management of anxiety and associated cognitive and functional impairments and its active phytochemicals alone or in combination as potential therapeutic agents. Expand
Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.
Various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury are summarized. Expand
Plant-based Rasayana drugs from Ayurveda
Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs. Expand
Phytopharmacology of Ashwagandha as an Anti-Diabetic Herb
Ashwagandha (Withania somnifera) extracts and several pharmaceutical formulations containing them are currently often used as tonics useful for prevention and cure of mental health problems,Expand
Ashwagandha: Ancient Medicine for Modern Times
The plant is a source of unique alkaloids and withanolides that have been shown to act as steroidal hormones and antioxidants with favorable impacts on human health, and several recent studies have provided evidence for its anti-stress, antioxidant, analgesic, anti-inflammatory,Anti-cancer, cardioprotective adaptogenic, anti spasmodic,munomodulatory and immunostimulant activity. Expand
An insight to curative effects of Ashwagandha (Withania somnifera), an Ayurveda herb
Ayurveda is the oldest form of medical sciences treats with the plant extracts. The plant produces secondary metabolites (phytochemicals). They pose as bioactive component act on many physiologicalExpand
Withania somnifera L. Dunal commonly known as Ginseng and Ashwagandha,a reputed plant of Indian and African traditional medicinal system is a member of Solanaceae family. Withanolides are the majorExpand
Withania somnifera: From Traditional Use to Evidence Based Medicinal Prominence
This review summarises the potential medicinal benefits of the W.somnifera and emphasizes that marketed product of the plant extracts for human consumption should scientifically validated for bioactive constitutents. Expand
Therapeutic impacts of Indian and Korean ginseng on human beings – a review
Indian and Korean ginseng balances the release of stress hormones by supporting the organs that produce them and works to enhance the immune system and protect the body from disease and stress. Expand


Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine
Some of the problems in evaluation of adaptogens which have precluded their inclusion as clinically useful drugs are discussed. Expand
Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas.
Investigation of the adaptogenic activity of ST against chronic unpredictable, but mild, footshock stress induced perturbations in behaviour (depression), glucose metabolism, suppressed male sexual behaviour, immunosuppression and cognitive dysfunction in CF strain albino rats indicates that ST has significantAdaptogenic activity, qualitatively comparable to PG, against a variety of behavioural, biochemical and physiological perturbation induced by unpredictable stress. Expand
Adaptogenic activity of Withania somnifera : an experimental study using a rat model of chronic stress
Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augmentExpand
Studies on Withania-ashwagandha, Kaul. V. The effect of total alkaloids (ashwagandholine) on the central nervous system.
The present paper deals with the neuro-pharmacological actions of the total alkaloids of Withania ashwagandha. Expand
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Expand
Antistressor effect of Withania somnifera.
Withania somnifera is an Indian medicinal plant used widely in the treatment of many clinical conditions in India. Its antistressor properties have been investigated in this study using adult WistarExpand
Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.
Significant increase in urine sodium, urine volume, significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density cholesterol) cholesterol were observed indicating that root of W. somnifera is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents. Expand
Adaptogenic activity of a novel withanolide‐free aqueous fraction from the roots of Withania somnifera Dun. (Part II)
In the Indian traditional system of medicine Withania somnifera Dun. is widely regarded as the Indian Ginseng. A new withanolide‐free hydrosoluble fraction was isolated from the roots of WithaniaExpand
Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment.
There was significant increase in body weight, food consumption and liver weight, and improved hematopoiesis was observed, and subacute toxicity studies in rats did not reveal any toxicity. Expand
Retracted:Nootropic‐like effect of ashwagandha (Withania somnifera L.) in mice
  • J. Dhuley
  • Medicine, Biology
  • Phytotherapy research : PTR
  • 2001
The above article has been retracted by agreement between the author, the Editor‐in‐Chief of Phytotherapy research (PTR) and John Wiley & Sons,Ltd. The retraction has been agreed due to inclusion ofExpand