Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells.

@article{Hahm2011WithaferinAS,
  title={Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells.},
  author={Eunice Hahm and Joomin Lee and Yi Huang and Shivendra V Singh},
  journal={Molecular carcinogenesis},
  year={2011},
  volume={50 8},
  pages={
          614-24
        }
}
We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits growth of MCF-7 and MDA-MB-231 human breast cancer cells in culture and MDA-MB-231 xenografts in vivo by causing apoptosis. However, the mechanism of WA-induced apoptosis is not fully understood. The present study was designed to systematically determine the role of tumor suppressor p53 and estrogen receptor-α (ER-α) in proapoptotic response to WA using… CONTINUE READING
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