Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells

@inproceedings{Suman2016WithaferinASA,
  title={Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells},
  author={Suman Suman and Trinath Prasad Das and Suman Sirimulla and Houda Alatassi and Murali K. Ankem and Chendil Damodaran},
  booktitle={Oncotarget},
  year={2016}
}
The oncogenic activation of AKT gene has emerged as a key determinant of the aggressiveness of colorectal cancer (CRC); hence, research has focused on targeting AKT signaling for the treatment of advanced stages of CRC. In this study, we explored the anti-tumorigenic effects of withaferin A (WA) on CRC cells overexpressing AKT in preclinical (in vitro and… CONTINUE READING