Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice

@inproceedings{Lee2016WithaferinAI,
  title={Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice},
  author={Jaemin Lee and Junli Liu and Xudong Feng and Mario Andr{\'e}s Salazar Hern{\'a}ndez and Patrick Mucka and Dorina Ibi and Jae Won Choi and Umut Ozcan},
  booktitle={Nature Medicine},
  year={2016}
}
The increasing global prevalence of obesity and its associated disorders points to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss. Obesity is characterized by hyperleptinemia and central leptin resistance. In an attempt to identify compounds that could reverse leptin resistance and thus promote weight loss, we analyzed a library of small molecules that have mRNA expression profiles similar to that of celastrol, a naturally… CONTINUE READING