Corpus ID: 42732228

Withaferin A inhibits hepatoma cell proliferation through induction of apoptosis and cell cycle arrest

@inproceedings{Zhou2016WithaferinAI,
  title={Withaferin A inhibits hepatoma cell proliferation through induction of apoptosis and cell cycle arrest},
  author={Y. Zhou and X. Yu and Jingjing Yao and C. Xu and Jian-Hui Huang and Y. Wan and Mei-Juan Wu},
  year={2016}
}
Withaferin A (WFA) is an active compound from Withania somnifera and has been reported to exhibit a variety of pharmacological activities such as anti-inflammatory and anti-cancer activities. In the present study, we investigated the anti-proliferative effect of WFA on human hepatocellular carcinoma (HCC) cells and the molecular mechanism underlying the cytotoxicity of WFA. We found that treatment with WFA obviously inhibited HCC cells proliferation in a dose and time-dependent manner. Moreover… Expand
1 Citations

Figures from this paper

References

SHOWING 1-10 OF 31 REFERENCES
Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation
Effect of Withaferin A on A549 cellular proliferation and apoptosis in non-small cell lung cancer.
Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma
...
1
2
3
4
...