Withaferin-A induces apoptosis in osteosarcoma U 2 OS cell line via generation of ROS and disruption of mitochondrial membrane potential

Abstract. – OBJECTIVE: Withaferin-A (WF-A) is a well-known dietary compound isolated from Withania somnifera. It has marked pharmacological potential and has been shown to exhibit antiproliferative activity against several types of cancerous cells. Currently, the main focus of anti-cancer therapeutic development is to identify apoptosis-inducing drug-like… CONTINUE READING