Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.

@article{Stan2008WithaferinAC,
  title={Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.},
  author={Silvia D. Stan and E S Hahm and Renaud Warin and Shivendra V Singh},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={7661-9}
}
Withaferin A (WA) is derived from the medicinal plant Withania somnifera, which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. We now show, for the first time, that WA exhibits significant activity against human breast cancer cells in culture and in vivo. The WA treatment decreased viability of MCF-7 (estrogen-responsive) and MDA-MB-231 (estrogen-independent) human breast cancer cells in a concentration-dependent manner. The WA-mediated… CONTINUE READING

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PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells.

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