Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation.

@article{Wijeratne2018WithaferinAA,
  title={Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation.},
  author={E. Wijeratne and M. C. F. Oliveira and J. Mafezoli and Ya-ming Xu and S. Minguzzi and P. H. J. Batista and O. D. Pessoa and L. Whitesell and A. Gunatilaka},
  journal={Journal of natural products},
  year={2018},
  volume={81 4},
  pages={
          825-837
        }
}
Withanolides constitute a valuable class of bioactive natural products because some members of the class are known to exhibit cytotoxic activity and also induce a cytoprotective heat-shock response. In order to understand the relationship between their structures and these dual bioactivities of the withanolide scaffold, we obtained 25 analogues of withaferin A (WA) and withanolide D (WD) including 17 new compounds by semisynthesis involving chemical and microbial transformations. Hitherto… Expand
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