Withaferin A Effectively Targets Soluble Vimentin in the Glaucoma Filtration Surgical Model of Fibrosis

@inproceedings{Bargagnamohan2013WithaferinAE,
  title={Withaferin A Effectively Targets Soluble Vimentin in the Glaucoma Filtration Surgical Model of Fibrosis},
  author={Paola Bargagna-mohan and Sunil P Deokule and Kyle Thompson and John W. Wizeman and Cidambi Srinivasan and Sunil K. Vooturi and Uday B. Kompella and Royce Mohan},
  booktitle={PloS one},
  year={2013}
}
Withaferin A (WFA) is a natural product that binds to soluble forms of the type III intermediate filament (IF) vimentin. Currently, it is unknown under what pathophysiological contexts vimentin is druggable, as cytoskeltal vimentin-IFs are abundantly expressed. To investigate druggability of vimentin, we exploited rabbit Tenon's capsule fibroblast (RbTCF) cell cultures and the rabbit glaucoma filtration surgical (GFS) model of fibrosis. WFA potently caused G₀/G₁ cell cycle inhibition (IC₅₀ 25… CONTINUE READING

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