Corpus ID: 83999082

Wirkung von Kreatin auf Neurodegeneration und Alterung

  title={Wirkung von Kreatin auf Neurodegeneration und Alterung},
  author={Tobias Bernd Ludwig Haack},


Creatine improves health and survival of mice
Data show that Cr improves health and longevity in mice, and may be a promising food supplement to promote healthy human aging. Expand
Mitochondrial DNA Mutations and Aging
Recent developments in aging research into the role that mtDNA mutations play in the aging process are focused on. Expand
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
It is shown that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA, suggesting that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease. Expand
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria were generated and the importance of mitochondria as a source of radicals was reinforced. Expand
Premature ageing in mice expressing defective mitochondrial DNA polymerase
The results provide a causative link between mtDNA mutations and ageing phenotypes in mammals by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase. Expand
The biology of aging.
  • B. Troen
  • Biology, Medicine
  • The Mount Sinai journal of medicine, New York
  • 2003
Increasing evidence suggests that cellular senescence and organismic aging are antagonistically pleiotropic manifestations of evolutionary pressures to prevent malignant transformation, and aging may be the price the authors pay to avoid cancer. Expand
Pigments in Aging: An Overview
  • E. Porta
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2002
Though it is widely believed that lipofuscin is a marker of oxidative stress, and that it can be modified by antioxidants and prooxidants, these assumptions are mainly based on in vitro experiments and are not generally supported by in vivo studies. Expand
The evolutionary theorie of aging
  • 1991
Lysosomes in iron metabolism, ageing and apoptosis
The lysosomal compartment is essential for a variety of cellular functions, including the normal turnover of most long-lived proteins and all organelles, and is also a mechanism by which cells will be able to sustain temporary starvation and rid themselves of intracellular organisms that have invaded. Expand