Corpus ID: 38068161

Wirksamkeit von oral verabreichtem Fluralaner ( Bravecto TM ) bzw . topisch verabreichtem Imidacloprid / Moxidectin ( Advocate ® ) bei

@inproceedings{Fourie2016WirksamkeitVO,
  title={Wirksamkeit von oral verabreichtem Fluralaner ( Bravecto TM ) bzw . topisch verabreichtem Imidacloprid / Moxidectin ( Advocate {\textregistered} ) bei},
  author={Josephus J Fourie and Julian E Liebenberg and Ivan G Horak and Janina Taenzler and A. R. Heckeroth and Regis Fr{\'e}nais},
  year={2016}
}
Hintergrund: Diese Laborstudie verglich die Wirksamkeit von BravectoTM (Fluralaner) als Kautablette mit der Wirksamkeit von Advocate® (Imidacloprid/Moxidectin) als topische Verabreichung bei natürlich erworbener generalisierter Demodikose bei Hunden. Methoden: Sechszehn Hunde, bei denen generalisierte Demodikose diagnostiziert wurde, wurden nach dem Zufallsprinzip zwei gleich großen Gruppen zugewiesen. Der einen Hundegruppe wurden die BravectoTM Kautabletten einmalig mit einer Mindestdosis von… Expand

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TLDR
It was concluded that weekly application of Advocate(®) can be recommended as effective for the treatment of canine generalized demodicosis without the potential for toxicity associated with ivermectin. Expand
Safety of fluralaner chewable tablets (BravectoTM), a novel systemic antiparasitic drug, in dogs after oral administration
TLDR
Oral administration of fluralaner at the highest recommended treatment dose (56 mg/kg) at 8-week intervals is well tolerated and has a safety margin of more than five in healthy dogs eight weeks of age or older and weighing at least 2 kg. Expand
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It appears that oral administration of milbemycin oxime, ivermectin, and moxidectin daily is a practical therapeutical alternative and would provide similar cure rates for dogs with resistant CGD. Expand
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Persistence of sebaceous gland hyperplasia after parasitological cure in some patients suggested that this histological finding may not always be resulting from Demodex infestation, and low numbers of adult mites and variable clinical responses to acaricidal therapy suggested a contributory rather than a major role of D. injai in this skin condition. Expand
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The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs
TLDR
Fluralaner kills ticks rapidly after treatment at 4 hours, and over its entire 12-week period of efficacy, it achieves an almost complete killing effect within 12 hours after tick infestation. Expand
Comparative Efficacy and Safety of Two Treatment Regimens with a Topically Applied Combination of Imidacloprid and Moxidectin (Advocate®) against Generalised Demodicosis in Dogs
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Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment
TLDR
Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment and completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Expand
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TLDR
In agreement with the superior RDL on-target activity, fluralaner outperformed dieldrin and fipronil in insecticidal screens on cat fleas (Ctenocephalides felis), yellow fever mosquito larvae (Aedes aegypti) and sheep blowfly larvae (Lucilia cuprina), as well as in acar suicidal screens on cattle tick (R. microplus) adult females and Ornithodoros moubata nymphs. Expand
A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs
TLDR
Bravecto™ (fluralaner) administered once orally to dogs in a chewable tablet was highly effective for 12 weeks against fleas and ticks on privately-owned dogs and was significantly non-inferior (ticks) and superior (fleas) in comparison with topical Frontline™ (fipronil) administered 3 times sequentially. Expand
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