Corpus ID: 38068161

Wirksamkeit von oral verabreichtem Fluralaner ( Bravecto TM ) bzw . topisch verabreichtem Imidacloprid / Moxidectin ( Advocate ® ) bei

  title={Wirksamkeit von oral verabreichtem Fluralaner ( Bravecto TM ) bzw . topisch verabreichtem Imidacloprid / Moxidectin ( Advocate {\textregistered} ) bei},
  author={Josephus J Fourie and Julian E Liebenberg and Ivan G Horak and Janina Taenzler and A. R. Heckeroth and Regis Fr{\'e}nais},
Hintergrund: Diese Laborstudie verglich die Wirksamkeit von BravectoTM (Fluralaner) als Kautablette mit der Wirksamkeit von Advocate® (Imidacloprid/Moxidectin) als topische Verabreichung bei natürlich erworbener generalisierter Demodikose bei Hunden. Methoden: Sechszehn Hunde, bei denen generalisierte Demodikose diagnostiziert wurde, wurden nach dem Zufallsprinzip zwei gleich großen Gruppen zugewiesen. Der einen Hundegruppe wurden die BravectoTM Kautabletten einmalig mit einer Mindestdosis von… Expand


Canine generalized demodicosis treated with varying doses of a 2.5% moxidectin+10% imidacloprid spot-on and oral ivermectin: parasiticidal effects and long-term treatment outcomes.
It was concluded that weekly application of Advocate(®) can be recommended as effective for the treatment of canine generalized demodicosis without the potential for toxicity associated with ivermectin. Expand
Safety of fluralaner chewable tablets (BravectoTM), a novel systemic antiparasitic drug, in dogs after oral administration
Oral administration of fluralaner at the highest recommended treatment dose (56 mg/kg) at 8-week intervals is well tolerated and has a safety margin of more than five in healthy dogs eight weeks of age or older and weighing at least 2 kg. Expand
New approaches to the treatment of canine demodicosis.
  • M. Paradis
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1999
It appears that oral administration of milbemycin oxime, ivermectin, and moxidectin daily is a practical therapeutical alternative and would provide similar cure rates for dogs with resistant CGD. Expand
Demodex injai infestation and dorsal greasy skin and hair in eight wirehaired fox terrier dogs.
Persistence of sebaceous gland hyperplasia after parasitological cure in some patients suggested that this histological finding may not always be resulting from Demodex infestation, and low numbers of adult mites and variable clinical responses to acaricidal therapy suggested a contributory rather than a major role of D. injai in this skin condition. Expand
Topical (pour-on) ivermectin in the treatment of chronic generalized demodicosis in dogs
Twelve privately owned dogs with chronic generalized demodicosis were treated topically along the dorsal midline with 1.5 mg kg−1 of 0.5% pour-on ivermectin for cattle three times per week for 3–6Expand
The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs
Fluralaner kills ticks rapidly after treatment at 4 hours, and over its entire 12-week period of efficacy, it achieves an almost complete killing effect within 12 hours after tick infestation. Expand
Comparative Efficacy and Safety of Two Treatment Regimens with a Topically Applied Combination of Imidacloprid and Moxidectin (Advocate®) against Generalised Demodicosis in Dogs
Dogs treated at weekly intervals exhibited markedly fewer clinical signs and greater hair regrowth and weight gain than those treated at 28-day intervals, and the safety of a weekly treatment interval in dogs was assessed. Expand
Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment
Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment and completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Expand
The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity.
In agreement with the superior RDL on-target activity, fluralaner outperformed dieldrin and fipronil in insecticidal screens on cat fleas (Ctenocephalides felis), yellow fever mosquito larvae (Aedes aegypti) and sheep blowfly larvae (Lucilia cuprina), as well as in acar suicidal screens on cattle tick (R. microplus) adult females and Ornithodoros moubata nymphs. Expand
A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs
Bravecto™ (fluralaner) administered once orally to dogs in a chewable tablet was highly effective for 12 weeks against fleas and ticks on privately-owned dogs and was significantly non-inferior (ticks) and superior (fleas) in comparison with topical Frontline™ (fipronil) administered 3 times sequentially. Expand