Wiring Optimization in Cortical Circuits

@article{Chklovskii2002WiringOI,
  title={Wiring Optimization in Cortical Circuits},
  author={D. Chklovskii and T. Schikorski and C. Stevens},
  journal={Neuron},
  year={2002},
  volume={34},
  pages={341-347}
}
Wiring a brain presents a formidable problem because neural circuits require an enormous number of fast and durable connections. We propose that evolution was likely to have optimized neural circuits to minimize conduction delays in axons, passive cable attenuation in dendrites, and the length of "wire" used to construct circuits, and to have maximized the density of synapses. Here we ask the question: "What fraction of the volume should be taken up by axons and dendrites (i.e., wire) when… Expand
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