Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’

@article{Raichlen2012WiredTR,
  title={Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’},
  author={David A. Raichlen and Adam D Foster and Gregory L. Gerdeman and Alexandre Seillier and Andrea Giuffrida},
  journal={Journal of Experimental Biology},
  year={2012},
  volume={215},
  pages={1331 - 1336}
}
Humans report a wide range of neurobiological rewards following moderate and intense aerobic activity, popularly referred to as the 'runner's high', which may function to encourage habitual aerobic exercise. [...] Key Method We measured circulating eCBs in humans, dogs (a cursorial mammal) and ferrets (a non-cursorial mammal) before and after treadmill exercise to test the hypothesis that neurobiological rewards are linked to high-intensity exercise in cursorial mammals. We show that humans and dogs share…Expand
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165 Citations

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Citation Type

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It is tempting to hypothesize that physical activity would represent a complementary alternative approach for the clinical management of endocannabinoid system deregulation in obesity, without the side effects occurring with CB1 receptor antagonists. Expand
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The results suggest that, at least in part, the promnesic effect of the exercise is dependent of CB1 receptor activation and is mediated by BDNF, which can be mimic by inhibition of anandamide hydrolysis in sedentary animals. Expand
Is Experimental Evolution of an Increased Aerobic Exercise Performance in Bank Voles Mediated by Endocannabinoid Signaling Pathway?
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The results corroborated involvement of endocannabinoids in the regulation of physical activity, but did not support the hypothesis that modification of endOCannabinoid signaling played a role in the evolution of increased aerobic exercise performance in the experimental evolution model. Expand
Endocannabinoids, exercise, pain, and a path to health with aging.
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  • Medicine
  • Molecular aspects of medicine
  • 2018
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Evidence is discussed for the role of eCB and the complexities of the ECS in exercise and pain, and how other types of exercise, such as Tai Chi, which is reported to improve well-being, should be investigated to ascertain if changes in eCB mediate the mind and body benefits of Tai Chi. Expand
Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?
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Unique dynamics in miRNA concentration occur in athletes with subjective/objective evidence of RH, targeting genes implicated endorphin, endocannabinoid, and GABAergic signaling. Expand
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