Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation

@inproceedings{Song2013Wip1SA,
  title={Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation},
  author={J-Y Song and S-H Ryu and Y M Cho and Mi Na Kim and B-M Lee and Sung Woo Lee and Jaewoo Choi},
  booktitle={Cell Death and Disease},
  year={2013}
}
Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that switches off DNA damage checkpoint responses by the dephosphorylation of certain proteins (i.e. p38 mitogen-activated protein kinase, p53, checkpoint kinase 1, checkpoint kinase 2, and uracil DNA glycosylase) involved in DNA repair and the cell cycle checkpoint. Emerging data indicate that Wip1 is amplified or overexpressed in various human tumors, and its detection implies a poor prognosis. In this… CONTINUE READING

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