Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.

@article{Goloudina2012Wip1SP,
  title={Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.},
  author={Anastasia R. Goloudina and Sharlyn J Mazur and Ettore Appella and Carmen Garrido and Oleg N. Demidov},
  journal={Cell cycle},
  year={2012},
  volume={11 10},
  pages={1883-7}
}
Wip1 is a stress-response phosphatase that negatively regulates several tumor suppressors, including p53. In a sizeable fraction of tumors, overexpression or amplification of Wip1 compromises p53 functions; inhibition of Wip1 activity is an attractive strategy for improving treatment of these tumors. However, over half of human tumors contain mutations in… CONTINUE READING