Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.

@article{Schito2006Wip1PM,
  title={Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.},
  author={Marco Schito and Oleg N. Demidov and Shin'ichi Saito and Jonathan D Ashwell and Ettore Appella},
  journal={Journal of immunology},
  year={2006},
  volume={176 8},
  pages={4818-25}
}
The PP2C phosphatase Wip1 dephosphorylates p38 and blocks UV-induced p53 activation in cultured human cells. Although the level of TCR-induced p38 MAPK activity is initially comparable between Wip1-/- and wild-type thymocytes, phosphatase-deficient cells failed to down-regulate p38 MAPK activity after 6 h. Analysis of young Wip1-deficient mice showed that they had fewer splenic T cells. Their thymi were smaller, contained significantly fewer cells, and failed to undergo age-dependent involution… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…