Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis

@inproceedings{Chen2016Wip1IG,
  title={Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis},
  author={Zhenghu Chen and Long Wang and Dayong Yao and Tianshu Yang and Wen-ming Cao and Jun Dou and Jonathan C. Pang and Shan Guan and Huiyuan Zhang and Yonghao Yu and Yanling Zhao and Yongfeng Wang and Xin Xu and Yan Shi and Roma H. Patel and Hong Zhang and Sanjeev A. Vasudevan and Shang-feng Liu and Jianhua Yang and Jed G. Nuchtern},
  booktitle={Scientific reports},
  year={2016}
}
Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a relatively low frequency in NB and the downstream function of p53 is intact in NB cell lines. Wip1 is a negative regulator of p53 and hindrance of Wip1 activity by novel inhibitor GSK2830371 is a potential strategy to activate p53's tumor suppressing function in NB. Yet, the in vivo efficacy and the possible mechanisms of GSK2830371 in NB… CONTINUE READING
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