Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells.

@article{Liu2011WinglessHW,
  title={Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells.},
  author={Xingyin Liu and Shaoping Wu and Yinglin Xia and Xi Li and Yuxuan Xia and Zhongren Zhou and Jun Sun},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={301 6},
  pages={G992-G1003}
}
Wnt11 plays an essential role in gastrointestinal epithelial proliferation, and previous investigations have focused on development and immune responses. However, the roles of how enteric bacteria regulate Wnt11 and how Wnt11 modulates the host response to pathogenic bacteria remain unexplored. This study investigated the effects of Salmonella infection on Wnt activation in intestinal epithelial cells. We found that Wnt11 mRNA and protein expression were elevated after Salmonella colonization… CONTINUE READING

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