Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines.

@article{Kampa2000WineAP,
  title={Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines.},
  author={Marilena Kampa and Anastassia Hatzoglou and Georgios Notas and Athina Damianaki and Efstathia Bakogeorgou and Claudia Gemetzi and Elias Kouroumalis and Pierre M. Martin and Elias Castanas},
  journal={Nutrition and cancer},
  year={2000},
  volume={37 2},
  pages={223-33}
}
The effect of different wine antioxidant polyphenols (catechin, epicatechin, quercetin, and resveratrol) on the growth of three prostate cancer cell lines (LNCaP, PC3, and DU145) was investigated. A dose- and time-dependent inhibition of cell growth by polyphenols was found at nanomolar concentrations. The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth… CONTINUE READING
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