Windows of detection of lorazepam in urine, oral fluid and hair, with a special focus on drug-facilitated crimes.

@article{Kintz2004WindowsOD,
  title={Windows of detection of lorazepam in urine, oral fluid and hair, with a special focus on drug-facilitated crimes.},
  author={Pascal Kintz and Marion Villain and Vincent Cirimele and Gilbert P{\'e}pin and Bertrand Ludes},
  journal={Forensic science international},
  year={2004},
  volume={145 2-3},
  pages={
          131-5
        }
}
Windows of Detection of Tetrazepam in Urine, Oral Fluid, Beard, and Hair, With a Special Focus on Drug-Facilitated Crimes
TLDR
In cases of drug-facilitated crimes in which tetrazepam is involved, hair and beard analyses can be an important complement to urine analyses to document exposure, particularly if LC-MS/MS is used.
Detection of diazepam in urine, hair and preserved oral fluid samples with LC-MS-MS after single and repeated administration of Myolastan® and Valium®
TLDR
It is demonstrated that diazepam can be observed in urine samples even after a single dose of Myolastan®, and the possible metabolic conversion of tetrazepam todiazepam is a more plausible explanation for the detection of diazep am in biological samples after the intake of Myoliastan®,.
Bioanalytical procedures for detection of chemical agents in hair in the case of drug-facilitated crimes
  • P. Kintz
  • Biology
    Analytical and bioanalytical chemistry
  • 2007
TLDR
Hair analysis may be a useful adjunct to conventional drug testing in sexual assault and should not be considered as an alternative to blood and urine analyses, but as a complement.
State of the art in hair analysis for detection of drug and alcohol abuse.
Value of the concept of minimal detectable dosage in human hair.
  • P. Kintz
  • Biology
    Forensic science international
  • 2012
Invited critical review State of the art in hair analysis for detection of drug and alcohol abuse
TLDR
Improved chromatographic–mass spectrometric techniques with increased selectivity and sensitivity and new methods of sample preparation have substantially enhanced the ability to detect numerous drugs and other poisons in hair.
Oral Fluid Toxicology
TLDR
Developments in the field of collection devices, pharmacokinetics of common drugs of abuse in oral fluid, and recent technological advances and guidelines that increase the actual use of oral fluid testing in a legal context and its acceptance by the criminal justice system are discussed.
A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure
TLDR
The results suggest that this comprehensive and sensitive hair analysis method can successfully verify a drug after a single exposure in crimes and can be applied in forensic and clinical toxicology laboratories.
The detection and quantification of lorazepam and its 3-O-glucuronide in fingerprint deposits by LC-MS/MS.
TLDR
Quantitative analysis for the benzodiazepine lorazepam and its 3-O-glucuronide conjugate in fingerprints following the oral administration of a single 2 mg dose of lorzepam to five volunteers indicates the first time a drug glucuronide has been detected in deposited fingerprints.
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References

SHOWING 1-10 OF 23 REFERENCES
Detection and quantification of lorazepam in human hair by GC-MS/NCI in a case of traffic accident
TLDR
A traffic accident caused by a man who declared that he was driving under influence of drugs (Temesta), led the laboratory to develop a procedure for the detection and the quantification of lorazepam in human hair that proved the driver had taken the drug over a long period of time.
Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid
TLDR
The detection times depend mainly on the dose and sensitivity of the method used, the preparation and route of administration, the duration of use, the matrix that is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and the interindividual variation in metabolic and renal clearance.
Testing for zolpidem in oral fluid by liquid chromatography-tandem mass spectrometry.
  • P. Kintz, M. Villain, B. Ludes
  • Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2004
Detection of flunitrazepam and 7-aminoflunitrazepam in oral fluid after controlled administration of rohypnol.
TLDR
In all cases the drug was detectable, but at extremely low concentrations, for 6 h after intake of a normal dose of Rohypnol and it will be an analytical challenge to come up with a sufficiently sensitive onsite test for low-dose benzodiazepines in oral fluid.
Testing for the Undetectable in Drug-Facilitated Sexual Assault Using Hair Analyzed by Tandem Mass Spectrometry as Evidence
TLDR
Hair analysis may be a useful adjunct to conventional drug testing in sexual assault and should not be considered as an alternative to blood and urine analyses but as a complement.
Testing for GHB in hair by GC/MS/MS after a single exposure. Application to document sexual assault.
TLDR
This study demonstrates that a single exposure to GHB in a case of sexual assault can be documented by hair analysis when collected about one month after the crime.
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