Windows of Detection of Tetrazepam in Urine, Oral Fluid, Beard, and Hair, With a Special Focus on Drug-Facilitated Crimes

@article{Concheiro2005WindowsOD,
  title={Windows of Detection of Tetrazepam in Urine, Oral Fluid, Beard, and Hair, With a Special Focus on Drug-Facilitated Crimes},
  author={Marta Concheiro and Marion Villain and Stephane Bouchet and Bertrand Ludes and Manuel L{\'o}pez-Rivadulla and Pascal Kintz},
  journal={Therapeutic Drug Monitoring},
  year={2005},
  volume={27},
  pages={565-570}
}
Reducing the capacity of a victim to react against sexual assault, coupled with a possible abrupt unconsciousness-inducing effect and ease of administration in spiked drinks, have resulted in the use of sedative agents in cases of drug-facilitated offence. Among these compounds, tetrazepam may impair an individual rapidly. The chances of detecting this substance increase if the most sensitive methods are used and if the biologic matrix that allows the longest possible detection time is… 
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References

SHOWING 1-10 OF 28 REFERENCES
Windows of detection of lorazepam in urine, oral fluid and hair, with a special focus on drug-facilitated crimes.
TLDR
Urine appears as the best specimen to document exposure, particularly if LC-MS/MS is used in case of drug-facilitated crimes involving lorazepam, and despite a limit of quantitation at 1 pg/mg, the authors were unable to detect a single lorzepam dose in hair, contrarily to most other benzodiazepines that are detectable.
Testing for the Undetectable in Drug-Facilitated Sexual Assault Using Hair Analyzed by Tandem Mass Spectrometry as Evidence
TLDR
Hair analysis may be a useful adjunct to conventional drug testing in sexual assault and should not be considered as an alternative to blood and urine analyses but as a complement.
Detection of thiopental and pentobarbital in head and pubic hair in a case of drug-facilitated sexual assault.
TLDR
Analytical findings from hair revealed the use of the anaesthetic agent thiopental to sedate the victim quickly and deeply and commit sexual assault.
Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid
TLDR
The detection times depend mainly on the dose and sensitivity of the method used, the preparation and route of administration, the duration of use, the matrix that is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and the interindividual variation in metabolic and renal clearance.
Testing for GHB in hair by GC/MS/MS after a single exposure. Application to document sexual assault.
TLDR
This study demonstrates that a single exposure to GHB in a case of sexual assault can be documented by hair analysis when collected about one month after the crime.
Detection of flunitrazepam and 7-aminoflunitrazepam in oral fluid after controlled administration of rohypnol.
TLDR
In all cases the drug was detectable, but at extremely low concentrations, for 6 h after intake of a normal dose of Rohypnol and it will be an analytical challenge to come up with a sufficiently sensitive onsite test for low-dose benzodiazepines in oral fluid.
Testing for zolpidem in oral fluid by liquid chromatography-tandem mass spectrometry.
  • P. Kintz, M. Villain, B. Ludes
  • Chemistry, Medicine
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2004
Deposition of 7-aminoflunitrazepam and flunitrazepam in hair after a single dose of Rohypnol.
TLDR
To determine whether flunitrazepam and its major metabolite 7-aminoflunitsepam could be detected in hair collected from ten healthy volunteers after receiving a single 2 mg dose of Rohypnol using solid phase extraction and NCI-GC-MS, and to determine the best time interval for hair collection from a victim of drug-facilitated sexual assault, is studied.
Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes.
TLDR
This method was applied in two forensic cases and allowed us to determine bromazepam in urine 3 days after the alleged offense and in cut head hair at a concentration of 6.7 pg/mg only in the 2-cm proximal segment.
...
1
2
3
...