Wilson disease and Menkes disease: new handles on heavy-metal transport.

  title={Wilson disease and Menkes disease: new handles on heavy-metal transport.},
  author={Peter C. Bull and Diane Wilson Cox},
  journal={Trends in genetics : TIG},
  volume={10 7},
Little is known at the molecular level about the homeostatic control of heavy-metal concentrations in mammals. Recently, however, two human diseases that disrupt copper transport, Menkes disease and Wilson disease, were found to be caused by mutations in two closely related genes, MNK and WND, which encode proteins belonging to the P-type ATPase family of cation transporters. The MNK and WND proteins are unique in having at their amino termini six copies of a sequence that is remarkably similar… CONTINUE READING
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