Wilson’s Disease: A Comprehensive Review of the Molecular Mechanisms

@inproceedings{Wu2015WilsonsDA,
  title={Wilson’s Disease: A Comprehensive Review of the Molecular Mechanisms},
  author={Fei Wu and Jing Wang and Chunwen Pu and Liang Qiao and Chunmeng Jiang},
  booktitle={International journal of molecular sciences},
  year={2015}
}
Wilson's disease (WD), also known as hepatolenticular degeneration, is an autosomal recessive inherited disorder resulting from abnormal copper metabolism. Reduced copper excretion causes an excessive deposition of the copper in many organs such as the liver, central nervous system (CNS), cornea, kidney, joints, and cardiac muscle where the physiological functions of the affected organs are impaired. The underlying molecular mechanisms for WD have been extensively studied. It is now believed… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 83 references

Solution structure of the N-domain of Wilson disease protein: Distinct nucleotide-binding environment and effects of disease mutations

  • O. Dmitriev, R. Tsivkoskii, F. Abildgaard, C. T. Morgan, H. L. Markley, S. Lutsenko
  • Proc. Natl. Acad. Sci. USA
  • 2006
Highly Influential
4 Excerpts

Long-term outcomes of patients with Wilson disease in a large Austrian cohort

  • S. Beinhardt, W. Leiss, +7 authors H Hofer
  • Clin. Gastroenterol. Hapatol
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…