Wilson's disease: assessment of D-penicillamine treatment.

@article{CaillieBertrand1985WilsonsDA,
  title={Wilson's disease: assessment of D-penicillamine treatment.},
  author={Micheline Van Caillie-Bertrand and Herman J. Degenhart and Ingrid H T Luijendijk and Jan Bouquet and Maarten Sinaasappel},
  journal={Archives of disease in childhood},
  year={1985},
  volume={60 7},
  pages={652-5}
}
Serum copper and zinc concentrations and 24 hour urinary copper and zinc excretion were determined serially from the beginning of treatment with D-penicillamine in four children with Wilson's disease. The data show a progressive decrease in both serum copper and zinc concentrations in all. Urinary copper excretion gradually levelled off to approximately 50% of initial values, but zinc excretion increased. Urinary zinc:copper ratios therefore increased with the duration of treatment. Copper… CONTINUE READING

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