Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

@article{Major2007WilmsTS,
  title={Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.},
  author={Michael B. Major and Nathan D Camp and Jason D. Berndt and Xianhua Yi and Seth James Goldenberg and Charlotte C. Hubbert and Travis L. Biechele and Anne-Claude Gingras and Ning Zheng and Michael J. MacCoss and St{\'e}phane Angers and Randall T. Moon},
  journal={Science},
  year={2007},
  volume={316 5827},
  pages={
          1043-6
        }
}
Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation of beta-catenin, the key effector of the WNT signaling pathway, results in stabilization of beta-catenin and, in turn, activation of transcription. We have used tandem-affinity protein purification and mass spectrometry to define the protein interaction network of the beta-catenin destruction complex. This assay revealed that WTX, a… CONTINUE READING

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